Product — Stem cell secretome
Stem cell secretome
Stem cell secretome (conditioned medium), manufactured in two formulations — freeze-dried and liquid-frozen — from three cell sources: adipose, deciduous tooth pulp, and umbilical cord. Our proprietary culture medium contains no animal-derived components, eliminating impurities at the manufacturing stage. We supply this high-purity preparation to medical institutions.
3 sources
Adipose / deciduous tooth pulp / umbilical cord
2 formulations
Freeze-dried / liquid-frozen
<0.1EU/mL
Endotoxin (tested on every lot)
10 vials+
Minimum lot; next-day delivery available
At a glance
Sterility testing
Every lot
Mycoplasma
Negative
Endotoxin
Below 0.1 EU/mL
Protein concentration
Lot-specific COA
Manufacturing facility
Ginza cleanroom
Specifications
Standard Specifications
To minimize impurities and lot-to-lot variability, we handle every step in-house, from donor selection to quality testing. The following specifications apply to all products.
| Item | Specification |
|---|---|
| Endotoxin testing | Every lot tested; below 0.1 EU/mL |
| Sterility testing | Performed on every lot (Japanese Pharmacopoeia direct inoculation method) |
| Mycoplasma testing | Confirmed negative by PCR |
| Certificate of Analysis (COA) | Issued per lot and shipped with the product |
| Cell source disclosure | Source, donor age, and health status disclosed |
| Formulations | Freeze-dried / liquid-frozen |
| Minimum order | From 10 vials |
| Onboarding support | Provided by our in-house physicians |
Manufacturing
Manufacturing Process
From donor selection to filling, every step takes place in our own cleanroom in Ginza, Tokyo. Quality checks at each stage keep lot-to-lot variability low.
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01Donor
Donor Screening
Health examination, infectious disease screening, and informed consent.
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02Culture
Cell Collection & Culture
Cells are cultured in the cleanroom under our own SOPs, with passage number and culture conditions tightly controlled.
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03Purify
Purification & Concentration
Impurities are removed by ultrafiltration membranes and tangential flow filtration.
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04QC
Quality Testing
Sterility, endotoxin, mycoplasma, and protein concentration are tested.
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05Ship
Filling & Shipping
After the COA is issued, products are packed refrigerated or frozen. Next-day delivery available.
Quality assurance
Quality Control
To deliver products that medical institutions can use with confidence, we run multiple quality tests on every single lot.
Release tests
- Sterility testing (every lot)
- Performed in accordance with the direct inoculation method of the Japanese Pharmacopoeia, 18th Edition. Products ship only after a negative result.
- Endotoxin testing (LAL assay)
- Quantitative measurement using Limulus amebocyte lysate reagent. Specification: below 0.1 EU/mL; every lot is tested and results are recorded on the lot-specific COA.
- Mycoplasma testing
- High-sensitivity detection by PCR, ruling out contamination during the culture process.
QC specification
| Test item | Specification | Result |
|---|---|---|
| Appearance | Colorless to pale yellow, clear | PASS |
| pH | 7.0 – 7.6 | PASS |
| Osmolality | 280 – 320 mOsm/kg | PASS |
| Endotoxin | < 0.1 EU/mL | PASS |
| Sterility | Negative | PASS |
| Mycoplasma | Negative | PASS |
| Total protein concentration | Within lot-specific specification | PASS |
| HGF / VEGF / IGF-1 | Detectable | PASS |
Test results are recorded on the lot-specific Certificate of Analysis (COA) shipped with each product.
Cell sources
Three Donor Sources
Cytokine profiles differ by cell source. Choose the source that fits your research purpose and application.
Adipose-Derived
Adipose-derived MSC
Abundant tissue availability enables stable lot-to-lot manufacturing. Rich in VEGF and HGF, this source has the most extensive track record in skin and tissue research.
Main research areasSkin & tissue
- Key factors
- HGFHigh
- VEGFHigh
- IGF-1Moderate
- FGF-2Moderate
Deciduous Tooth Pulp-Derived
Dental pulp stem cell
Collected from childhood deciduous teeth. Derived from young stem cells with high proliferative and differentiation capacity, and rich in neurotrophic factors such as BDNF and NGF. Applied research is advancing in the neurological and hair-loss (AGA) fields.
Main research areasNeurological & hair
- Key factors
- BDNFHigh
- NGFHigh
- FGF-2High
- HGFModerate
Umbilical Cord-Derived
Umbilical cord MSC
Collected from the umbilical cord immediately after birth. Rich in anti-inflammatory cytokines. Applied research is advancing in the immunology and inflammation fields.
Main research areasImmunology & inflammation
- Key factors
- IL-10High
- TGF-βHigh
- IDOHigh
- VEGFModerate
Factor levels shown indicate relative tendencies compared across the three sources.
Formulations
Two Formulations
Choose freeze-dried or liquid-frozen to suit your facility's storage environment and usage frequency. Both are manufactured to the same quality standards, in 1mL vials.
| Item | Freeze-dried | Liquid-frozen |
|---|---|---|
| Storage | At room temperature, protected from light (up to 40°C) | Frozen (−20°C or below) |
| Shelf life | 2 years from manufacture | 1 year from manufacture |
| Recommended use period | Within the expiration date on the label | Within 6 months of delivery |
| Preparation | Add approximately 1mL of purified water or physiological saline per 1mL | Thaw at room temperature (about 5 minutes); invert gently to mix before opening |
| Volume | 1mL / vial | 1mL / vial |
| Shipping | Refrigerated courier (year-round) | Frozen shipping with ice packs |
| Features | No freezer required; stores at room temperature protected from light; suited to long-term storage | No cryoprotectant; retains more active factors; ready to use right after thawing |
| Best suited for | Facilities without freezer equipment, or those planning long-term inventory | Facilities with a −20°C freezer and high usage frequency |
Freeze-dried products can also be shipped at room temperature; however, considering the possibility of temperatures exceeding 40°C in transit, all shipments have used refrigerated courier year-round since April 7, 2026 (Notice on product storage conditions). After arrival, products may be stored at room temperature as long as it remains at or below 40°C.
This product contains no preservatives. Handle it under aseptic conditions and use it as soon as possible after opening. Because the human stem cell-derived protein components in the liquid-frozen type may gradually denature even while frozen, we recommend use within 6 months of delivery.
Shelf life is counted from the date of manufacture. For the actual expiration date, check the label on each vial (How freeze-drying enables room-temperature storage).
Customer support
Onboarding Support
For medical institutions introducing stem cell secretome for the first time, our in-house physicians provide continuous support from onboarding through routine use.
Protocols & Literature
We provide product handling protocols and a list of relevant academic literature.
Technical Consultation with Physicians
TechnoCell's in-house physicians are available for individual consultations on product selection, usage, and management of adverse reactions.
Patient Information Materials
We provide patient information sheets and consent form templates — materials to support properly obtained informed consent.
Trial Introduction Plan
First orders start from a minimum of 10 vials, and you can move to regular ordering after evaluation. We recommend starting with a small-scale evaluation.
Next-Day Delivery
Orders placed by 14:00 on weekdays arrive as early as the next day (next morning within Tokyo; within 2 business days elsewhere). We maintain inventory levels that can respond to urgent cases.
Pricing
Pricing
Prices are disclosed on the member page after registration (shown excluding tax; 10% Japanese consumption tax applies). Orders can be placed directly from the member page.
| Product | Source | Formulation | Volume | Price (excl. tax / vial) |
|---|---|---|---|---|
| Stem Cell Secretome | Adipose | Freeze-dried | 1mL | Disclosed after registration |
| Stem Cell Secretome | Adipose | Liquid-frozen | 1mL | Disclosed after registration |
| Stem Cell Secretome | Deciduous tooth pulp | Freeze-dried | 1mL | Disclosed after registration |
| Stem Cell Secretome | Deciduous tooth pulp | Liquid-frozen | 1mL | Disclosed after registration |
| Stem Cell Secretome | Umbilical cord | Freeze-dried | 1mL | Disclosed after registration |
| Stem Cell Secretome | Umbilical cord | Liquid-frozen | 1mL | Disclosed after registration |
- Minimum order is 10 vials.
- A packing and shipping fee of ¥2,000 excluding tax (¥2,200 including tax) applies per order.
- Payment is by invoice: charges are closed at month-end and due on the 20th of the following month.
FAQ
Frequently Asked Questions
Read more about the difference between conditioned medium and secretome
Get started
Start with Membership Registration
Once your application is approved, the ordering system is available right away. If you have any questions, feel free to contact us.